Cold Promoted Activation of Factor VII

H Gjønniess

doi:10.1055/s-0038-1649054

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1972; 28(02): 182-193
DOI: 10.1055/s-0038-1649054

Original Article

Schattauer GmbH

Cold Promoted Activation of Factor VII

III. Relation to the Kallikrein System

H Gjønniess

¹Institute for Thrombosis Research, University of Oslo, Rikshospitalet, (Chief: H. Stormorken) Oslo, Norway

› Author Affiliations

Abstract

Summary

Several known activators of the plasma kallikrein system were tested for the ability to induce cold promoted activation of factor VII.

All the prekallikrein activators tested (EACA, trypsin, acetone, urokinase, kaolin, Liquoid, ellagic acid) revealed generation of factor VII activator activity (CPA). Simultaneously the plasma kallikrein system was activated. A good correlation was demonstrated between the factor VII activation and the kallikrein activity.

Glandular kallikrein, bradykinin, or kallidin revealed no effect on the coagulation system. Thus, the correlation between the factor VII activation and the kallikrein system seemed to be restricted to plasma kallikrein.

Full Text

References

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